• 72°

Guest Opinion: What do Honeycrisp apples, Google and COVID-19 have in common?

By John Fraser

Scientists have responded to COVID-19 with unprecedented speed. Just months after the outbreak of the novel coronavirus, clinical trials are already underway for nearly 200 vaccines and therapies.

But while the pace of COVID-19 innovation may be extraordinary, the research infrastructure allowing this remarkable work is hardly new. In fact, it was cemented into place nearly two generations ago when Congress passed the Bayh-Dole Act of 1980.

That reform laid the groundwork for a system of partnerships between publicly funded universities and private companies that has produced some of the world’s greatest drug breakthrough innovations.

This uniquely American research model is the foundation for much of the COVID-19 research taking place today.

Public-private partnerships are hardly unique to biotech innovation. Run a Google search for “Honeycrisp apple” and you’ll find it had its origins in a lab at the University of Minnesota.

Oh, and that Google search engine you just used? Co-founder Sergei Brin had a National Science Foundation Fellowship for graduate students at Stanford University as he was developing it.

Breakthroughs like these often build upon very basic research inquiries, funded, in part, by the federal government. But historically, any resulting discoveries were owned by the government — not the inventor. As a result, the discoveries would often lay dormant. Before Bayh-Dole became law, the federal government licensed less than 5 percent of the patented inventions it retained.

Recognizing that thousands of scientific breakthroughs were gathering dust — and that taxpayers weren’t benefiting from the research they helped fund — Senators Birch Bayh and Bob Dole stepped in to accelerate public-private collaboration.

Their legislation, the Bayh-Dole Act, enabled universities to retain ownership of patented inventions developed with federal funding — and then license those patents to private companies, who take on enormous risks and spend millions, or even billions, of dollars to research and develop new medicines.

In the biomedical field, risk of failure is very high. Fewer than 12 percent of candidates that enter Phase I clinical trials eventually make it to the market.

Universities are ill-suited for drug development. Public research dollars are best spent on what universities are really good at — making basic discoveries and pushing the boundaries of science — while private capital underwrites the high-risk trial-and-error work of turning these discoveries into real-world medicines.

Bayh-Dole ignited an explosion of U.S. innovation by bringing the two together and providing incentives to work together for the betterment of America, creating hundreds of thousands of jobs since then. Bayh-Dole has proven so successful that countries like Japan, Brazil, Singapore, China, and Malaysia have all implemented some version of it.

It’s no surprise, then, that America’s model of biomedical innovation has been indispensable to the current COVID-19 response.

For instance, the Massachusetts-based biotech firm Moderna — a company spun out of MIT — identified a leading vaccine candidate for the novel coronavirus in just 42 days and is about to begin phase III human trials.The revolutionary mRNA technology used to develop the candidate stems, in part, from research done at the University of Pennsylvania and Harvard.

With the Bayh-Dole Act, the United States found a way to foster collaboration between universities, government agencies, and private companies to turn laboratory science into lifesaving inventions. This model has worked astoundingly well for years. In this time of crisis, it’s more valuable than ever and also stands ready to address future challenges.

John Fraser is a past president of AUTM, the global association of academic technology transfer professionals. This piece originally ran in the International Business Times.



Duck begins search for new town manager


Milltail Road reopens on Alligator River Refuge


John Harris of Kitty Hawk Kites honored for contributions to tourism in North Carolina


Moratorium on offshore drilling reportedly coming for North Carolina


Film production resumes in North Carolina


Trump taps Barrett for Supreme Court


Recognized for 20 years of service at Town of Manteo


COVID-19 testing event set in Fairfield


Victim in Camden County shooting in coma


Lost woman found at Cape Hatteras National Seashore in Buxton


Additional COVID-19 related deaths reported in Currituck and Tyrrell


Moyock development vote fails to get approval from Currituck Board of Commissioners


State graduation rate continues to climb, local administrators weigh in


Feds want to relax protections for woodpecker endangered since 1970


Three North Carolina death row inmates to serve life in prison


GOP elections board members in NC resign over absentee deal


Capital projects for Dare County water system approved


Dare occupancy collections set a record for July


Manteo annexes vacant lot


Belted kingfishers prefer to be near water


Jennette’s Pier staff members pick peers for excellence awards


North Carolina Coastal Federation receives marine debris removal grant from NOAA


First responders traverse ocean overwash on NC 12 to get child to hospital


Sections of NC 12 on Hatteras and Ocracoke islands to reopen Thursday at noon